RLN1

Across TCGA cell cohorts, RLN1 mutation is significantly associated with the mutation status of many other genes, with 1,117 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible RLN1-associated genes across cancer lineages are PARP9, DDX31, and EPS8L1. Each is linked with RLN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RLN1-to-partner and partner-to-RLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP9 grouped by RLN1-low versus RLN1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLN1→partner) and Y-score (partner→RLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PARP9 →	+5.415	+5.415	.004	.004	1	4
SKIN	DDX31 →	+5.824	+5.824	.002	.002	1	2
SKIN	EPS8L1 →	+4.824	+5.392	.004	.004	1	2
OVARY	PCED1A →	+5.415	+5.415	.004	.004	1	2
OVARY	TEX2 →	+4.415	+4.977	.007	.007	1	2
SKIN	MARCHF7 →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,117 associations by consensus.

PARP9 by RLN1 expression — OVARY

Explore this box plot interactively →