RLN1

Across TCGA pan-cancer cohorts, RLN1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RLN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RLN1 RNA is repressed in tumor relative to normal tissue. In most cancer types RLN1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where RLN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RLN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.452	<.001	11	view →
KICH	Male	All	−0.844	<.001	10	view →
BLCA	All	All	+0.470	<.001	8	view →
LUAD	Female	II,III,IV	−0.290	.003	3	view →
BRCA	All	All	+0.176	.009	3	view →
CHOL	All	All	+0.178	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RLN1–KIRC

Open the KIRC breakdown →