Across TCGA patient cohorts, RING1 mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RING1-associated genes across cancer lineages are OFD1P1Y, FGF7P5, and HPRT1P2. Each is linked with RING1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RING1-to-partner and partner-to-RING1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RING1→partner) and Y-score (partner→RING1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OFD1P1Y →	+0.068	+4.624	<.001	.005	3	3
UCEC	FGF7P5 →	+0.043	+4.390	<.001	.003	3	2
UCEC	HPRT1P2 →	+0.041	+2.920	<.001	.008	3	2
UCEC	RN7SL478P →	+0.223	+2.202	<.001	.001	3	2
COAD	FAM204DP →	+0.155	+4.993	.005	.002	3	2
COAD	RPS29P32 →	+0.556	+5.251	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

Exploration

RING1 survival (RNA) · tumor vs normal (RNA) · all RING1 data types