RIN1

Across TCGA patient cohorts, RIN1 mutation is significantly associated with the RNA expression of many other genes, with 3,722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIN1-associated genes across cancer lineages are GUSBP17, HNRNPA3P8, and OR7A8P. Each is linked with RIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIN1-to-partner and partner-to-RIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUSBP17 grouped by RIN1-low versus RIN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN1→partner) and Y-score (partner→RIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GUSBP17 →	+0.117	+2.866	.004	.001	3	2
SKCM	HNRNPA3P8 →	+0.054	+2.396	.008	.009	3	2
CESC	OR7A8P →	+0.064	+3.760	.001	.007	3	2
BRCA	MTHFD2P3 →	+0.180	+4.760	<.001	.007	3	2
UCEC	LINC00624 →	+0.354	+2.173	.003	.002	3	2
UCEC	MAPRE1 →	+0.416	+1.818	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

GUSBP17 by RIN1 expression — SKCM

Explore this box plot interactively →