RIN1

Across TCGA pan-cancer cohorts, RIN1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RIN1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RIN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIN1 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where RIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.845	<.001	11	view →
COAD	Male	III,IV	+1.458	<.001	11	view →
KIRC	Male	All	+1.354	<.001	11	view →
KIRP	All	III,IV	+1.743	<.001	9	view →
HNSC	Male	All	+1.175	<.001	9	view →
LIHC	All	II,III,IV	+0.743	<.001	8	view →
STAD	Male	II,III,IV	+1.323	<.001	6	view →
LUAD	Female	II,III,IV	+0.808	<.001	6	view →
UCEC	All	All	−0.787	<.001	6	view →
LUSC	Male	All	+1.067	<.001	5	view →
READ	All	All	+0.941	<.001	5	view →
CHOL	Male	All	+1.901	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RIN1–THCA

Open the THCA breakdown →