RIMS1

Across TCGA patient cohorts, RIMS1 mutation is significantly associated with the RNA expression of many other genes, with 7,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIMS1-associated genes across cancer lineages are HAUS1, BUB3, and SKA1. Each is linked with RIMS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both RIMS1-to-partner and partner-to-RIMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS1 grouped by RIMS1-low versus RIMS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS1→partner) and Y-score (partner→RIMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAUS1 →	+0.482	+1.324	<.001	<.001	3	6
UCEC	BUB3 →	+0.434	+1.395	<.001	<.001	3	6
UCEC	SKA1 →	+0.608	+1.406	<.001	<.001	3	6
STAD	H2AZ1 →	+0.566	+3.940	<.001	<.001	3	6
STAD	MAD2L1 →	+0.859	+3.923	<.001	<.001	3	6
UCEC	CENPN →	+0.652	+1.634	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,535 associations by consensus.

HAUS1 by RIMS1 expression — UCEC

Explore this box plot interactively →