RIMS1

Across TCGA pan-cancer cohorts, RIMS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RIMS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RIMS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIMS1 is over-expressed in tumor, although a few such as STAD and LUSC show the opposite, repressed pattern.

BRCA, STAD, and KICH are the cancer types where RIMS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIMS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	+0.448	.014	6	view →
STAD	Female	All	−0.734	<.001	5	view →
KICH	All	All	+0.922	.004	3	view →
LUSC	All	III,IV	−0.331	.011	3	view →
PRAD	All	All	+0.297	.046	2	view →
ESCA	All	All	−0.268	.004	2	view →
READ	Female	All	−0.200	.023	2	view →
PAAD	All	All	−0.047	.029	2	view →
CHOL	All	All	+0.171	.039	1	view →
KIRP	Male	All	−0.036	.041	1	view →
KIRC	Male	All	−0.028	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RIMS1–BRCA

Open the BRCA breakdown →