RIMS1

Across TCGA pan-cancer cohorts, RIMS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RIMS1 data layer compared with 13 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RIMS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RIMS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and LGG show a favorable association.

BLCA, UCEC, and KIRC are the cancer types where RIMS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	IV	0.108	0.570	<.001	113	view →
UCEC	OS	Median	All	0.827	0.906	.001	108	view →
KIRC	DFS	Tertile	IV	0.363	0.754	<.001	59	view →
UVM	DFS	Tertile	All	0.439	0.990	<.001	35	view →
MESO	OS	Tertile	III,IV	0.881	0.376	.006	21	view →
ACC	OS	Tertile	IV	0.344	0.724	.038	19	view →
BRCA	DFS	Tertile	All	0.456	0.652	.002	18	view →
KIRP	OS	Quartile	II,III,IV	0.592	0.859	.002	18	view →
LGG	DFS	Median	All	0.870	0.792	.002	12	view →
LIHC	OS	Median	II,III,IV	0.532	0.350	.020	12	view →
PRAD	DFS	Quartile	All	0.897	0.686	.016	12	view →
PAAD	DFS	Tertile	All	0.432	0.178	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RIMS1–BLCA (OS)

Open the BLCA breakdown →