RIMS1

Across TCGA cell cohorts, RIMS1 mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIMS1-associated genes across cancer lineages are ITGAE, PRKACG, and OR4F21. Each is linked with RIMS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIMS1-to-partner and partner-to-RIMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by RIMS1-low versus RIMS1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS1→partner) and Y-score (partner→RIMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ITGAE →	+0.544	+2.502	.002	.005	3	3
PANCREAS	PRKACG →	+0.005	+4.614	<.001	.004	3	2
BLOOD_Lymphoma	OR4F21 →	+0.051	+4.219	<.001	<.001	3	2
BLOOD_Lymphoma	OR52K1 →	+0.009	+3.169	<.001	.008	3	2
BREAST	OR10T2 →	+0.110	+4.196	<.001	.006	3	2
SKIN	PHIP →	+0.488	+2.502	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

ITGAE by RIMS1 expression — SKIN

Explore this box plot interactively →