RHOQ

Across TCGA patient cohorts, RHOQ mutation is significantly associated with the RNA expression of many other genes, with 402 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOQ-associated genes across cancer lineages are OR51A6P, CHEK2P5, and RNA5SP423. Each is linked with RHOQ in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOQ-to-partner and partner-to-RHOQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51A6P grouped by RHOQ-low versus RHOQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOQ→partner) and Y-score (partner→RHOQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR51A6P →	+0.034	+2.912	.006	.009	3	2
UCEC	CHEK2P5 →	+0.118	+2.773	.006	.004	3	2
UCEC	RNA5SP423 →	+0.884	+2.717	<.001	<.001	3	2
LUSC	MIR1224 →	+0.541	+6.438	<.001	.001	3	2
BLCA	OR8A3P →	+0.341	+5.411	<.001	.005	3	2
BLCA	MIR3913-1 →	+0.567	+5.497	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 402 associations by consensus.

OR51A6P by RHOQ expression — UCEC

Explore this box plot interactively →