RHOQ

Across TCGA pan-cancer cohorts, RHOQ RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RHOQ data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RHOQ RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RHOQ expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

UVM, LUAD, and LGG are the cancer types where RHOQ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.231	0.815	<.001	67	view →
LUAD	OS	Quartile	II,III,IV	0.839	0.621	<.001	56	view →
LGG	OS	Median	All	0.707	0.907	<.001	54	view →
LIHC	OS	Median	All	0.609	0.758	<.001	49	view →
STAD	DFS	Median	III,IV	0.510	0.651	.012	36	view →
KICH	OS	Median	II,III,IV	0.883	1.000	.006	34	view →
UCS	OS	Quartile	III,IV	0.563	0.214	.022	30	view →
BRCA	OS	Tertile	IV	0.934	0.325	.002	28	view →
SARC	OS	Median	All	0.821	0.664	<.001	23	view →
BLCA	DFS	Median	IV	0.586	0.359	.002	20	view →
CESC	DFS	Median	All	0.764	0.876	<.001	16	view →
COAD	DFS	Quartile	All	0.592	0.816	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RHOQ–UVM (DFS)

Open the UVM breakdown →