RHOH

Across TCGA cell cohorts, RHOH mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHOH-associated genes across cancer lineages are DEFB129, GML, and TCF21. Each is linked with RHOH in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOH-to-partner and partner-to-RHOH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by RHOH-low versus RHOH-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOH→partner) and Y-score (partner→RHOH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.021	+4.022	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TCF21 →	+0.019	+4.705	<.001	.003	3	1
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	1
BLOOD_Leukemia	LRIT1 →	+0.046	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GPR26 →	+0.057	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DEFB129 by RHOH expression — SKIN

Explore this box plot interactively →