RHOH

Across TCGA pan-cancer cohorts, RHOH RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RHOH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RHOH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHOH is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

KIRC, LUSC, and BRCA are the cancer types where RHOH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHOH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.472	<.001	11	view →
LUSC	All	II,III,IV	−0.792	<.001	6	view →
BRCA	All	II,III,IV	+0.789	<.001	6	view →
BLCA	All	All	−0.736	.008	6	view →
COAD	Female	II,III,IV	−0.649	<.001	6	view →
HNSC	All	All	+0.430	.007	4	view →
STAD	Female	All	+1.180	.025	3	view →
UCEC	All	All	−0.349	.026	2	view →
ESCA	All	All	+1.001	.032	1	view →
CHOL	All	All	+0.698	.038	1	view →
THCA	All	All	−0.504	.037	1	view →
KIRP	All	All	+0.322	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RHOH–KIRC

Open the KIRC breakdown →