RHO

Across TCGA cell cohorts, RHO mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHO-associated genes across cancer lineages are FBXW10, ESX1, and JAM2. Each is linked with RHO in more than 1 cancer types. Because this analysis shows association rather than direction, both RHO-to-partner and partner-to-RHO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by RHO-low versus RHO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHO→partner) and Y-score (partner→RHO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.308	+3.491	<.001	.004	3	2
LARGE_INTESTINE	ESX1 →	+0.014	+2.882	.006	.005	3	1
LARGE_INTESTINE	JAM2 →	+0.460	+3.228	.006	.009	3	1
LARGE_INTESTINE	SSMEM1 →	+0.035	+3.292	<.001	.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+2.933	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.088	+2.892	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FBXW10 by RHO expression — LARGE_INTESTINE

Explore this box plot interactively →