RHO

Across TCGA pan-cancer cohorts, RHO RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RHO data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RHO RNA is associated with better overall survival. In most high-consensus cancer types, elevated RHO expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, KIRP, and KIRC are the cancer types where RHO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.431	0.292	.001	46	view →
KIRP	OS	Tertile	All	0.536	0.796	.005	35	view →
KIRC	DFS	Tertile	All	0.542	0.686	.003	32	view →
UVM	DFS	Tertile	All	0.432	0.988	<.001	28	view →
BLCA	DFS	Quartile	All	0.529	0.648	.006	27	view →
LUSC	OS	Tertile	II,III,IV	0.253	0.447	.013	25	view →
PAAD	OS	Quartile	II,III,IV	0.440	0.624	.007	24	view →
STAD	DFS	Quartile	All	0.261	0.530	.022	23	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	18	view →
DLBC	DFS	Tertile	All	0.531	0.898	.010	14	view →
MESO	DFS	Quartile	IV	0.224	0.597	.020	12	view →
ACC	OS	Tertile	III,IV	0.414	0.816	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RHO–SKCM (OS)

Open the SKCM breakdown →