RHEX

Across TCGA patient cohorts, RHEX RNA expression is significantly associated with the protein abundance of many other proteins, with 16,565 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHEX-associated proteins across cancer lineages are TOP2A_S1525, TRIM28_S697, and TRMT5. Each is linked with RHEX in more than 4 cancer types. Because this analysis shows association rather than direction, both RHEX-to-partner and partner-to-RHEX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHEX versus TOP2A_S1525 in LSCC, with a Pearson correlation of -0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEX→partner) and Y-score (partner→RHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP2A_S1525 →	-0.969	-0.620	<.001	<.001	3	5
LUAD	TRIM28_S697 →	-1.130	-0.946	<.001	<.001	3	5
LSCC	TRMT5 →	-0.335	-0.732	<.001	<.001	3	5
COAD	MSN →	+0.400	+0.711	<.001	<.001	3	5
LSCC	MYBBP1A_S1267 →	-0.554	-0.661	<.001	<.001	3	5
UCEC	NOC2L_S49 →	-0.509	-0.962	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,565 associations by consensus.

RHEX vs TOP2A_S1525 — LSCC

Explore this scatter interactively →