RHEX

Across TCGA pan-cancer cohorts, RHEX RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RHEX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RHEX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHEX is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where RHEX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHEX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.945	<.001	12	view →
COAD	All	IV	−1.217	<.001	12	view →
HNSC	All	All	+0.972	<.001	11	view →
KICH	Female	All	−3.389	<.001	10	view →
KIRP	Male	III,IV	+2.191	<.001	9	view →
LUAD	Female	III,IV	−1.150	<.001	9	view →
LUSC	Male	II,III,IV	−1.318	<.001	7	view →
UCEC	All	All	+2.224	<.001	6	view →
READ	All	All	−1.098	<.001	5	view →
BLCA	Male	III,IV	−1.564	.026	3	view →
PRAD	All	All	−1.025	<.001	2	view →
CHOL	All	All	+2.348	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RHEX–KIRC

Open the KIRC breakdown →