RHEB

Across TCGA patient cohorts, RHEB mutation is significantly associated with the RNA expression of many other genes, with 375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHEB-associated genes across cancer lineages are NTM-AS1, MED15P1, and MIR3666. Each is linked with RHEB in more than 1 cancer types. Because this analysis shows association rather than direction, both RHEB-to-partner and partner-to-RHEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTM-AS1 grouped by RHEB-low versus RHEB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEB→partner) and Y-score (partner→RHEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NTM-AS1 →	+0.129	+2.646	.001	.009	3	2
UCEC	MED15P1 →	+0.043	+4.075	<.001	.007	3	2
UCEC	MIR3666 →	+0.262	+3.708	<.001	.002	3	1
UCEC	ZNHIT3 →	+0.593	+3.343	.002	.005	3	1
UCEC	RPS29P32 →	+0.512	+2.792	<.001	.006	3	1
UCEC	HNRNPCL3 →	+0.059	+2.930	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 375 associations by consensus.

NTM-AS1 by RHEB expression — UCEC

Explore this box plot interactively →