RHEB

Across TCGA pan-cancer cohorts, RHEB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RHEB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RHEB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHEB is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where RHEB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHEB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.941	<.001	12	view →
KIRP	All	III,IV	+0.831	<.001	10	view →
LIHC	Male	III,IV	+1.497	<.001	9	view →
COAD	Male	All	+0.851	<.001	9	view →
LUAD	Male	All	+0.615	<.001	8	view →
BRCA	All	II,III,IV	+0.319	<.001	6	view →
LUSC	Male	All	+0.440	<.001	5	view →
CHOL	Male	All	+1.556	<.001	2	view →
ESCA	All	All	+1.047	.003	2	view →
READ	All	III,IV	+0.694	.033	2	view →
KICH	Female	All	−0.539	.021	2	view →
PRAD	All	All	−0.264	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RHEB–HNSC

Open the HNSC breakdown →