RGS2

Across TCGA cell cohorts, RGS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,485 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RGS2-associated GO terms across cancer lineages are Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, and Negative regulation of cell growth involved in cardiac muscle cell development. Each is linked with RGS2 in more than 15 cancer types. Because this analysis shows association rather than direction, both RGS2-to-partner and partner-to-RGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway grouped by RGS2-low versus RGS2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS2→partner) and Y-score (partner→RGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway →	+1.352	+1.430	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway →	+0.739	+1.967	<.001	<.001	3	13
LIVER	Negative regulation of cell growth involved in cardiac muscle cell development →	+0.139	+2.398	.003	<.001	3	12
LIVER	Regulation of cell growth involved in cardiac muscle cell development →	+0.140	+2.121	<.001	<.001	3	12
LIVER	Negative regulation of cardiac muscle tissue growth →	+0.181	+2.240	.001	<.001	3	11
LIVER	Negative regulation of heart growth →	+0.181	+2.240	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,485 associations by consensus.

Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway by RGS2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →