RGS14

Across TCGA patient cohorts, RGS14 mutation is significantly associated with the RNA expression of many other genes, with 4,885 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS14-associated genes across cancer lineages are GUSBP16, UHRF1, and RNU2-62P. Each is linked with RGS14 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS14-to-partner and partner-to-RGS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUSBP16 grouped by RGS14-low versus RGS14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS14→partner) and Y-score (partner→RGS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GUSBP16 →	+0.072	+2.463	.002	.004	3	3
UCEC	UHRF1 →	+0.898	+2.747	<.001	<.001	3	2
LUAD	RNU2-62P →	+0.433	+4.722	<.001	.003	3	2
SKCM	RNU6-411P →	+0.615	+3.875	<.001	.006	3	2
UCEC	RMI1 →	+0.598	+1.858	.003	.005	3	2
UCEC	GEMIN4 →	+0.566	+3.606	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,885 associations by consensus.

GUSBP16 by RGS14 expression — COAD

Explore this box plot interactively →