RGS14

Across TCGA pan-cancer cohorts, RGS14 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RGS14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGS14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGS14 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where RGS14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.724	<.001	12	view →
KIRP	Male	II,III,IV	+1.815	<.001	11	view →
COAD	All	III,IV	+0.886	<.001	11	view →
THCA	Male	All	−0.761	<.001	10	view →
LUAD	Female	III,IV	+0.962	<.001	8	view →
KICH	Female	II,III,IV	−1.227	<.001	7	view →
LIHC	Male	All	+1.063	<.001	6	view →
BRCA	All	All	+0.555	<.001	6	view →
READ	All	All	+1.052	<.001	5	view →
BLCA	Male	All	+0.532	.036	3	view →
CHOL	All	All	+1.048	.002	2	view →
STAD	Female	All	+0.904	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RGS14–KIRC

Open the KIRC breakdown →