RGS14

Across TCGA pan-cancer cohorts, RGS14 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RGS14 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RGS14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RGS14 expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

UVM, LIHC, and LGG are the cancer types where RGS14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.422	0.797	.001	85	view →
LIHC	OS	Tertile	All	0.570	0.752	<.001	59	view →
LGG	OS	Median	All	0.756	0.861	<.001	48	view →
LAML	DFS	Tertile	All	0.401	0.758	.002	40	view →
ACC	DFS	Quartile	II,III,IV	0.205	0.673	.003	27	view →
KIRP	DFS	Median	All	0.856	0.974	<.001	27	view →
GBM	OS	Quartile	All	0.303	0.531	<.001	26	view →
UCS	DFS	Median	IV	0.416	0.909	.008	18	view →
KICH	OS	Median	II,III,IV	0.647	0.928	.013	18	view →
OV	OS	Quartile	All	0.887	0.791	.001	16	view →
DLBC	DFS	Median	All	0.332	0.858	.004	16	view →
HNSC	DFS	Quartile	All	0.719	0.551	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RGS14–UVM (DFS)

Open the UVM breakdown →