RGS14

Across TCGA patient cohorts, RGS14 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS14-associated genes across cancer lineages are RAD51, MEK1, and Annexin-1. Each is linked with RGS14 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS14-to-partner and partner-to-RGS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by RGS14-low versus RGS14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS14→partner) and Y-score (partner→RGS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.114	+1.502	.026	.030	3	3
UCEC	MEK1 →	+0.324	+2.222	.015	.010	3	2
UCEC	Annexin-1 →	+0.524	+2.604	.006	.005	3	2
UCEC	ASNS →	+0.432	+2.584	.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.130	-2.700	.003	.006	3	1
UCEC	ERK2 →	+0.158	+2.115	.025	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

RAD51 by RGS14 expression — UCEC

Explore this box plot interactively →