RGS14

Across TCGA cell cohorts, RGS14 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,948 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS14-associated GO terms across cancer lineages are Negative regulation of synaptic plasticity, Negative regulation of MAP kinase activity, and Proton motive force-driven mitochondrial ATP synthesis. Each is linked with RGS14 in more than 18 cancer types. Because this analysis shows association rather than direction, both RGS14-to-partner and partner-to-RGS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of synaptic plasticity grouped by RGS14-low versus RGS14-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS14→partner) and Y-score (partner→RGS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of synaptic plasticity →	+1.858	+2.103	<.001	<.001	3	19
OESOPHAGUS	Negative regulation of MAP kinase activity →	+0.123	+1.426	.002	.007	2	12
CNS	Proton motive force-driven mitochondrial ATP synthesis →	+0.081	+1.055	<.001	.002	3	10
CNS	Proton motive force-driven ATP synthesis →	+0.081	+1.152	<.001	.001	3	9
CNS	ATP synthesis coupled electron transport →	+0.080	+1.021	<.001	.001	3	9
CNS	Mitochondrial ATP synthesis coupled electron transport →	+0.080	+1.021	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,948 associations by consensus.

Negative regulation of synaptic plasticity by RGS14 expression — OESOPHAGUS

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