RGS14

Across TCGA cell cohorts, RGS14 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGS14-associated genes across cancer lineages are OTOR, TERB2, and APOL5. Each is linked with RGS14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS14-to-partner and partner-to-RGS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by RGS14-low versus RGS14-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS14→partner) and Y-score (partner→RGS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	TERB2 →	+0.050	+5.087	<.001	.004	3	1
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	NGF →	+0.562	+3.594	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.182	+3.567	<.001	.003	3	1
BLOOD_Leukemia	CD1B →	+4.901	+3.619	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OTOR by RGS14 expression — URINARY_TRACT

Explore this box plot interactively →