RGS11

Across TCGA cell cohorts, RGS11 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS11-associated genes across cancer lineages are SCYGR5, FMO1, and BPIFB6. Each is linked with RGS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS11-to-partner and partner-to-RGS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYGR5 grouped by RGS11-low versus RGS11-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS11→partner) and Y-score (partner→RGS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SCYGR5 →	+0.220	+5.169	<.001	.004	3	1
LARGE_INTESTINE	FMO1 →	+0.179	+3.777	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2J3 →	+0.044	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SCYGR5 by RGS11 expression — BONE

Explore this box plot interactively →