RGS11

Across TCGA pan-cancer cohorts, RGS11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RGS11’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RGS11 RNA is repressed in tumor relative to normal tissue. In most cancer types RGS11 is over-expressed in tumor, although a few such as BLCA and HNSC show the opposite, repressed pattern.

BLCA, HNSC, and KIRC are the cancer types where RGS11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.205	<.001	11	view →
HNSC	Male	All	−0.488	<.001	8	view →
KIRC	All	III,IV	−0.248	<.001	8	view →
LUAD	Male	All	−0.769	<.001	6	view →
LUSC	Female	II,III,IV	−1.179	<.001	5	view →
STAD	All	All	−0.754	<.001	4	view →
KICH	Female	II,III,IV	−0.480	.010	3	view →
THCA	All	All	+0.374	<.001	3	view →
UCEC	All	IV	+1.700	.032	2	view →
CHOL	Female	All	+1.250	.025	2	view →
PRAD	All	All	+0.690	<.001	2	view →
KIRP	All	All	−0.349	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RGS11–BLCA

Open the BLCA breakdown →