RGS1

Across TCGA cell cohorts, RGS1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS1-associated genes across cancer lineages are MSGN1, TFDP3, and TAFA1. Each is linked with RGS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS1-to-partner and partner-to-RGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by RGS1-low versus RGS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS1→partner) and Y-score (partner→RGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.069	+3.930	.002	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.336	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.044	+4.882	<.001	<.001	3	1
LARGE_INTESTINE	DAZ2 →	+0.204	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSGN1 by RGS1 expression — LARGE_INTESTINE

Explore this box plot interactively →