RGS1

Across TCGA pan-cancer cohorts, RGS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RGS1 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RGS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RGS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

ACC, HNSC, and UVM are the cancer types where RGS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.375	0.796	<.001	67	view →
HNSC	DFS	Tertile	III,IV	0.727	0.506	<.001	58	view →
UVM	DFS	Tertile	All	0.363	0.763	.002	47	view →
CESC	DFS	Tertile	All	0.830	0.651	.002	46	view →
LGG	DFS	Tertile	All	0.650	0.818	<.001	40	view →
STAD	OS	Tertile	All	0.499	0.669	.003	36	view →
LUAD	DFS	Median	II,III,IV	0.607	0.301	<.001	31	view →
BLCA	OS	Quartile	IV	0.691	0.463	.009	13	view →
CHOL	DFS	Tertile	II,III,IV	0.685	0.098	.015	12	view →
LIHC	OS	Median	III,IV	0.475	0.725	.010	12	view →
COAD	DFS	Median	IV	0.369	0.593	.012	9	view →
LUSC	DFS	Median	II,III,IV	0.296	0.444	.021	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RGS1–ACC (OS)

Open the ACC breakdown →