RGS1

Across TCGA pan-cancer cohorts, RGS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RGS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGS1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

KIRC, KIRP, and BLCA are the cancer types where RGS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.385	<.001	12	view →
KIRP	Male	All	+2.629	<.001	7	view →
BLCA	All	All	−1.128	.003	7	view →
STAD	All	All	+1.004	.007	7	view →
COAD	All	All	−0.746	.002	5	view →
BRCA	All	II,III,IV	+0.870	<.001	4	view →
LUAD	All	All	+0.739	.001	4	view →
THCA	Male	II,III,IV	+1.466	.024	3	view →
ESCA	All	All	+2.407	.006	2	view →
LIHC	Male	All	−0.884	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RGS1–KIRC

Open the KIRC breakdown →