RGN

Across TCGA pan-cancer cohorts, RGN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RGN data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RGN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RGN expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where RGN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.742	0.339	.005	42	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	40	view →
PDAC	OS	Quartile	III,IV	1.000	0.298	.006	27	view →
LUAD	OS	Tertile	All	1.000	0.579	.002	18	view →
HNSC	DFS	Tertile	IV	0.926	0.611	.005	7	view →
GBM	OS	Quartile	All	0.260	0.491	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RGN–CCRCC (DFS)

Open the CCRCC breakdown →