RFXANK

Across TCGA patient cohorts, RFXANK mutation is significantly associated with the RNA expression of many other genes, with 387 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFXANK-associated genes across cancer lineages are CDKN2AIPNLP3, SNX18P10, and LINC01338. Each is linked with RFXANK in more than 1 cancer types. Because this analysis shows association rather than direction, both RFXANK-to-partner and partner-to-RFXANK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN2AIPNLP3 grouped by RFXANK-low versus RFXANK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFXANK→partner) and Y-score (partner→RFXANK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDKN2AIPNLP3 →	+0.107	+4.199	<.001	.009	3	2
BRCA	SNX18P10 →	+0.044	+5.757	<.001	.001	3	1
UCEC	LINC01338 →	+0.478	+2.630	<.001	.005	3	1
SKCM	LINC01386 →	+0.333	+3.578	<.001	.007	3	1
SKCM	LINC01385 →	+0.541	+4.565	<.001	<.001	3	1
SKCM	RNA5SP436 →	+0.181	+4.328	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 387 associations by consensus.

CDKN2AIPNLP3 by RFXANK expression — SKCM

Explore this box plot interactively →