RFXANK

Across TCGA pan-cancer cohorts, RFXANK RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RFXANK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RFXANK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFXANK is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, BLCA, and COAD are the cancer types where RFXANK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFXANK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.755	<.001	12	view →
BLCA	Male	All	+0.960	<.001	11	view →
COAD	Female	All	+0.680	<.001	11	view →
LIHC	Female	II,III,IV	+1.806	<.001	9	view →
KIRP	Male	II,III,IV	+0.733	<.001	9	view →
HNSC	Male	IV	+0.924	<.001	8	view →
READ	Male	All	+0.630	<.001	7	view →
UCEC	All	All	+0.996	<.001	6	view →
LUSC	Female	All	+0.644	<.001	6	view →
STAD	Male	II,III,IV	+0.623	<.001	6	view →
BRCA	All	All	+0.487	<.001	6	view →
CHOL	All	All	+2.683	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RFXANK–KIRC

Open the KIRC breakdown →