RFX3

Across TCGA patient cohorts, RFX3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,494 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RFX3-associated genes across cancer lineages are GPNMB, CCDC173, and IFI16. Each is linked with RFX3 in more than 4 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RFX3 versus GPNMB in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPNMB →	-1.385	-0.414	<.001	<.001	3	4
GBM	CCDC173 →	+0.839	+0.560	<.001	<.001	3	4
UCEC	IFI16 →	-0.824	-0.307	<.001	.002	3	4
UCEC	MARCKSL1 →	+0.871	+0.323	<.001	.002	2	5
LSCC	AK3 →	+0.607	+0.489	<.001	<.001	3	4
HNSC	NFIB →	+0.963	+0.689	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,494 associations by consensus.

RFX3 vs GPNMB — GBM

Explore this scatter interactively →