RFX3

Across TCGA patient cohorts, RFX3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX3-associated genes across cancer lineages are Caspase-8, XBP1, and Fibronectin. Each is linked with RFX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by RFX3-low versus RFX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.206	-2.388	.014	.002	3	3
SKCM	XBP1 →	-0.298	-3.000	.033	.036	3	2
UCEC	Fibronectin →	-0.245	-1.687	.026	.040	3	2
UCEC	ACVRL1 →	-0.138	-2.687	.002	.005	3	2
UCEC	C-Raf →	+0.130	+1.807	.006	.025	3	2
UCEC	Cyclin-B1 →	+0.550	+2.584	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-8 by RFX3 expression — UCEC

Explore this box plot interactively →