RFX3

Across TCGA cell cohorts, RFX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,609 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RFX3-associated GO terms across cancer lineages are Positive regulation of type B pancreatic cell development, Heterochromatin organization, and Heterochromatin formation. Each is linked with RFX3 in more than 15 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type B pancreatic cell development grouped by RFX3-low versus RFX3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of type B pancreatic cell development →	-0.393	-1.248	<.001	<.001	3	16
LUNG_SCLC	Heterochromatin organization →	+0.083	+1.147	<.001	<.001	3	15
LUNG_SCLC	Heterochromatin formation →	+0.096	+1.284	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.093	+1.528	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of chromosome condensation →	+0.120	+1.055	<.001	.001	3	14
LUNG_SCLC	Positive regulation of myoblast differentiation →	+0.120	+1.398	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,609 associations by consensus.

Positive regulation of type B pancreatic cell development by RFX3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →