RFX3

Across TCGA cell cohorts, RFX3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,908 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFX3-associated genes across cancer lineages are VRK1, GLRX5, and TDP1. Each is linked with RFX3 in more than 11 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RFX3 versus VRK1 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	VRK1 →	+1.625	+1.489	.002	.001	3	12
BONE	GLRX5 →	+1.006	+1.519	.008	.006	3	9
BREAST	TDP1 →	+0.680	+0.980	.004	<.001	3	9
BLOOD_Myeloma	UBR7 →	+1.323	+1.327	.001	.005	3	9
STOMACH	PPP4R3A →	+1.015	+1.307	.002	<.001	3	7
CNS	SETD3 →	+0.789	+1.067	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,908 associations by consensus.

RFX3 vs VRK1 — UPPER_AERODIGESTIVE_TRACT

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