RFX3

Across TCGA cell cohorts, RFX3 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,724 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFX3-associated GO terms across cancer lineages are Cell cycle checkpoint signaling, Regulation of Schwann cell differentiation, and Folic acid-containing compound metabolic process. Each is linked with RFX3 in more than 6 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle checkpoint signaling grouped by RFX3-low versus RFX3-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Cell cycle checkpoint signaling →	+0.027	+0.517	.006	.001	3	7
CNS	Regulation of Schwann cell differentiation →	+0.149	+1.006	<.001	.001	3	6
LARGE_INTESTINE	Folic acid-containing compound metabolic process →	+0.076	+0.561	.002	.002	3	5
BLOOD_Leukemia	Regulation of endoplasmic reticulum unfolded protein response →	-0.087	-0.440	.003	.004	3	5
LARGE_INTESTINE	Interstrand cross-link repair →	+0.050	+0.649	<.001	<.001	3	5
OVARY	Lipid translocation →	-0.075	-1.095	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,724 associations by consensus.

Cell cycle checkpoint signaling by RFX3 expression — LUNG_NSCLC_LUAD

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