RFX3

Across TCGA cell cohorts, RFX3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RFX3-associated genes across cancer lineages are LCE1F, PRAMEF33, and C1QC. Each is linked with RFX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1F grouped by RFX3-low versus RFX3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCE1F →	+0.298	+4.384	<.001	.006	3	2
SKIN	PRAMEF33 →	+0.023	+5.415	<.001	.004	3	2
LUNG_SCLC	C1QC →	+0.031	+4.169	<.001	.001	3	1
LUNG_SCLC	C1QA →	+0.285	+4.070	<.001	.003	3	1
LUNG_SCLC	KRTAP8-1 →	+0.044	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

LCE1F by RFX3 expression — BLOOD_Leukemia

Explore this box plot interactively →