RFPL4B

Across TCGA patient cohorts, RFPL4B mutation is significantly associated with the RNA expression of many other genes, with 2,146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL4B-associated genes across cancer lineages are COTL1P2, KIF1C, and ZNF25-DT. Each is linked with RFPL4B in more than 2 cancer types. Because this analysis shows association rather than direction, both RFPL4B-to-partner and partner-to-RFPL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COTL1P2 grouped by RFPL4B-low versus RFPL4B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL4B→partner) and Y-score (partner→RFPL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COTL1P2 →	+0.199	+4.735	<.001	.001	3	3
UCEC	KIF1C →	+0.374	+1.869	.009	.005	3	3
STAD	ZNF25-DT →	+0.285	+3.078	.007	.007	3	3
UCEC	PPP2R2A →	+0.586	+2.930	<.001	<.001	3	3
UCEC	MTFP1 →	+0.724	+3.818	<.001	<.001	3	3
UCEC	RBM15 →	+0.536	+3.732	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,146 associations by consensus.

COTL1P2 by RFPL4B expression — HNSC

Explore this box plot interactively →