RFPL4B

Across TCGA pan-cancer cohorts, RFPL4B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RFPL4B data layer compared with 2 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher RFPL4B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RFPL4B expression acts as an unfavorable survival marker, although some lineages such as LGG and CHOL show a favorable association.

SCLC, KIRP, and LUAD are the cancer types where RFPL4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.125	0.465	.002	109	view →
KIRP	DFS	Median	All	0.721	0.942	<.001	99	view →
LUAD	OS	Quartile	All	0.724	0.834	<.001	53	view →
LGG	OS	Median	All	0.866	0.757	<.001	46	view →
COAD	DFS	Tertile	IV	0.307	0.526	.017	26	view →
STAD	DFS	Median	IV	0.171	0.670	.006	23	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.133	.010	18	view →
READ	DFS	Tertile	III,IV	0.318	0.801	.002	18	view →
LIHC	OS	Quartile	All	0.380	0.566	.007	15	view →
THCA	OS	Tertile	IV	0.871	1.000	.008	14	view →
KIRC	OS	Tertile	II,III,IV	0.788	0.634	.014	13	view →
UCS	OS	Tertile	IV	0.773	0.306	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RFPL4B–SCLC (OS)

Open the SCLC breakdown →