RFC4

Across TCGA patient cohorts, RFC4 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFC4-associated genes across cancer lineages are IGHD2-15, TCEA1P1, and TEX36-AS1. Each is linked with RFC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC4-to-partner and partner-to-RFC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-15 grouped by RFC4-low versus RFC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC4→partner) and Y-score (partner→RFC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGHD2-15 →	+1.396	+3.926	<.001	.005	3	2
UCEC	TCEA1P1 →	+0.090	+2.376	<.001	.007	3	2
UCEC	TEX36-AS1 →	+0.230	+2.454	<.001	.002	3	2
COAD	RNU6-878P →	+0.406	+5.693	<.001	.003	3	1
COAD	GUSBP17 →	+0.179	+5.080	.002	.008	3	1
COAD	MIR5590 →	+0.722	+6.392	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

IGHD2-15 by RFC4 expression — BLCA

Explore this box plot interactively →