RFC2

Across TCGA patient cohorts, RFC2 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFC2-associated genes across cancer lineages are RNA5SP386, NPBWR2, and PPP1R2P5. Each is linked with RFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC2-to-partner and partner-to-RFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP386 grouped by RFC2-low versus RFC2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC2→partner) and Y-score (partner→RFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP386 →	+0.332	+5.008	<.001	.004	3	2
CESC	NPBWR2 →	+0.056	+5.010	<.001	.009	3	2
UCEC	PPP1R2P5 →	+0.067	+3.027	<.001	.007	3	2
SKCM	MTND1P33 →	+0.028	+5.039	<.001	.003	3	2
BLCA	RN7SL248P →	+0.231	+5.618	<.001	.002	3	2
KIRC	OR4F8P →	+0.044	+8.025	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

RNA5SP386 by RFC2 expression — LIHC

Explore this box plot interactively →