RFC2

Across TCGA pan-cancer cohorts, RFC2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated RFC2 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RFC2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RFC2 expression acts as an unfavorable survival marker, although some lineages such as DLBC and OV show a favorable association.

ACC, UVM, and MESO are the cancer types where RFC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.262	0.630	<.001	134	view →
UVM	DFS	Median	All	0.405	0.811	<.001	118	view →
MESO	OS	Median	All	0.257	0.494	<.001	114	view →
KICH	DFS	Median	III,IV	0.216	1.000	<.001	106	view →
LIHC	DFS	Median	All	0.461	0.621	<.001	77	view →
LGG	OS	Median	All	0.356	0.551	<.001	53	view →
DLBC	DFS	Median	All	1.000	0.364	.001	34	view →
LUAD	OS	Tertile	All	0.313	0.451	.003	33	view →
PAAD	DFS	Median	All	0.345	0.579	.001	30	view →
OV	OS	Tertile	IV	0.630	0.330	.001	26	view →
UCEC	OS	Quartile	All	0.895	0.977	.003	26	view →
KIRP	OS	Tertile	All	0.794	0.916	.008	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

RFC2–ACC (DFS)

Open the ACC breakdown →