REV3L-IT1

Across TCGA pan-cancer cohorts, REV3L-IT1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated REV3L-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher REV3L-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated REV3L-IT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

KIRC, BLCA, and KIRP are the cancer types where REV3L-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.398	0.602	.006	26	view →
BLCA	OS	Tertile	All	0.642	0.387	.010	21	view →
KIRP	DFS	Median	III,IV	0.847	0.213	.005	20	view →
LUAD	DFS	Median	All	0.419	0.203	.003	19	view →
UVM	OS	Tertile	II,III,IV	0.608	0.863	.028	15	view →
COAD	OS	Median	III,IV	0.825	0.446	.021	13	view →
THYM	DFS	Tertile	All	1.000	0.778	.019	13	view →
SARC	OS	Tertile	All	0.389	0.584	.012	12	view →
BRCA	OS	Tertile	IV	0.669	0.226	.016	9	view →
KICH	OS	Quartile	II,III,IV	0.702	0.927	.003	9	view →
ACC	DFS	Tertile	IV	0.593	0.147	.048	9	view →
LGG	DFS	Quartile	All	0.293	0.599	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

REV3L-IT1–KIRC (DFS)

Open the KIRC breakdown →