Q-omics provides the consensus-scored REV3L-IT1 profile across patient tissues and cancer cell-line models. REV3L-IT1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, REV3L-IT1 is differentially expressed in 2, with the highest sampling consensus in KICH. Additionally, REV3L-IT1 RNA expression shows 8,673 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, KICH, and GBM as cancer lineages where REV3L-IT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for REV3L-IT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes REV3L-IT1 survival associations across molecular data types. REV3L-IT1 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible REV3L-IT1 RNA expression–survival associations across cancer types. High REV3L-IT1 expression shows unfavorable associations in KIRC and UVM, but favorable associations in BLCA, KIRP, LUAD and COAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .006). Together, the overview and detailed table identify KIRC as the clearest survival context for REV3L-IT1 RNA expression.
This table summarizes REV3L-IT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for REV3L-IT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. REV3L-IT1 shows lower tumor expression in KICH and COAD. The KICH box plot shows higher REV3L-IT1 RNA expression in normal versus tumor tissue (log2 FC = −0.102, t-test p = .005).
This table shows molecular features associated with REV3L-IT1 in patient tissues and cancer cell lines. In patient samples, REV3L-IT1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
