REV3L-IT1

Across TCGA pan-cancer cohorts, REV3L-IT1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of REV3L-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where REV3L-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types REV3L-IT1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH and COAD are the cancer types where REV3L-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REV3L-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.102	.005	3	view →
COAD	All	IV	−0.181	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

REV3L-IT1–KICH

Open the KICH breakdown →