RETSAT

Across TCGA patient cohorts, RETSAT mutation is significantly associated with the RNA expression of many other genes, with 914 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RETSAT-associated genes across cancer lineages are RNU6-206P, RNU4-84P, and OR6K1P. Each is linked with RETSAT in more than 2 cancer types. Because this analysis shows association rather than direction, both RETSAT-to-partner and partner-to-RETSAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-206P grouped by RETSAT-low versus RETSAT-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RETSAT→partner) and Y-score (partner→RETSAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-206P →	+0.264	+5.327	<.001	.002	3	3
HNSC	RNU4-84P →	+0.436	+6.339	<.001	.001	3	2
BLCA	OR6K1P →	+0.058	+5.497	<.001	.004	3	2
BLCA	TUBB8P3 →	+0.070	+5.038	<.001	.009	3	2
HNSC	GPM6BP3 →	+0.292	+7.357	<.001	<.001	3	2
HNSC	H2BP8 →	+0.157	+5.578	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

RNU6-206P by RETSAT expression — LUAD

Explore this box plot interactively →