RETSAT

Across TCGA pan-cancer cohorts, RETSAT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RETSAT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RETSAT RNA is repressed in tumor relative to normal tissue. In most cancer types RETSAT is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and BRCA are the cancer types where RETSAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RETSAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.885	<.001	11	view →
THCA	Male	III,IV	−1.281	<.001	11	view →
BRCA	All	II,III,IV	−1.200	<.001	6	view →
READ	All	All	−1.298	<.001	5	view →
LUSC	Male	II,III,IV	−0.539	<.001	5	view →
KICH	Female	All	−0.646	.003	4	view →
HNSC	Male	II,III,IV	−0.444	.009	4	view →
LUAD	All	All	−0.292	<.001	3	view →
CHOL	All	All	−0.735	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RETSAT–COAD

Open the COAD breakdown →